* Conference Event
% Exhibition/Scrimmage Event
Event times are (ET)
| August |
| | 26 | 1:00PM | Freed-Hardeman | vs. | Pikeville | 2-2 | (2OT) |
| | Played at Johnson Central High School in Paintsville | |
| | 29 | 2:00PM | Midway College | @ | Pikeville | 0-3 | |
| September |
| | 3 | | Pikeville | vs. | Central Baptist College | 0-1 | |
| | Lions Cup Tournament at Freed-Hardeman | |
| | 4 | 3:00PM | Pikeville | vs. | Lambuth University | 0-3 | |
| | Lions Cup 2010 @ Freed-Hardeman | |
| | 6 | | Pikeville | @ | Freed-Hardeman | 0-5 | |
| | Lions Cup Tournament at Freed-Hardeman | |
| | 14 | 2:00PM | Pikeville | @ | Kentucky Christian | 4-1 | |
| * | 18 | 2:00PM | Pikeville | @ | St. Catharine | 1-2 | |
| * | 21 | 3:00PM | Lindsey Wilson | @ | Pikeville | 4-0 | |
| | 25 | 1:00PM | Pikeville | @ | Mountain State University | 7-1 | |
| * | 30 | 7:00PM | West Virginia U. Tech | @ | Pikeville | 0-1 | |
| October |
| * | 6 | 7:00PM | Shawnee State | @ | Pikeville | 3-1 | |
| * | 9 | 6:00PM | Pikeville | @ | Campbellsville | 0-6 | |
| | Finley Stadium | |
| | 12 | 2:00PM | Pikeville | @ | Tennessee Temple | 3-2 | (OT) |
| * | 16 | 2:00PM | Pikeville | @ | Cumberlands (KY) | 0-6 | |
| * | 22 | 4:00PM | Pikeville | @ | Georgetown | 0-2 | |
| * | 25 | 5:00PM | Pikeville | @ | Rio Grande | 1-3 | |
| | Practice Field | |
| | 27 | 7:00PM | Pikeville | @ | Berea College | 11-1 | |
| November |
| | 2 | | Pikeville | @ | West Virginia U. Tech | 0-5 | |
| | Mid-South Conference Tournament -- Opening Round | |
* Conference Event
% Exhibition/Scrimmage Event
Event times are (ET)
