* Conference Event
% Exhibition/Scrimmage Event
Event times are (ET)
| August |
| * | 28 | 7:00PM | Lindsey Wilson | vs. | Pikeville | 6-0 | |
| September |
| | 3 | | Pikeville | @ | Freed-Hardeman | 1-4 | |
| | 2010 Lions Cup | |
| | 4 | | Pikeville | vs. | Johnson University | 1-3 | |
| | 2010 Lions Cup | |
| | 8 | 2:30PM | Pikeville | vs. | Benedictine University | 0-3 | |
| | Home contest for PC played at Prestonsburg, Ky. | |
| | 14 | | Pikeville | @ | Kentucky Christian | 2-0 | |
| * | 18 | 4:00PM | Pikeville | @ | St. Catharine | 0-4 | |
| | 25 | 3:00PM | Mountain State University | @ | Pikeville | 7-0 | |
| * | 30 | 9:00PM | West Virginia U. Tech | @ | Pikeville | 3-0 | |
| October |
| | 4 | | Pikeville | @ | Salem International University | 2-2 | |
| * | 6 | 9:00PM | Shawnee State | @ | Pikeville | 1-0 | |
| * | 9 | 8:00PM | Pikeville | @ | Campbellsville | 0-5 | |
| | Finley Stadium | |
| * | 16 | 4:00PM | Pikeville | @ | Cumberlands (KY) | 0-9 | |
| * | 18 | 3:00PM | Pikeville | @ | Georgetown | 1-3 | |
| * | 29 | 7:00PM | Pikeville | @ | Rio Grande | 0-11 | |
| November |
| | 2 | 3:00PM | Pikeville | @ | St. Catharine | 1-5 | |
| | Play in game MSC Tournament | |
* Conference Event
% Exhibition/Scrimmage Event
Event times are (ET)
