* Conference Event
% Exhibition/Scrimmage Event
Event times are (ET)
| March |
| | 1 | 5:00PM | St. Catharine | @ | Centre College | 6-4 | |
| | | Game 2 | St. Catharine | @ | Centre College | 12-13 | |
| | 2 | 2:00PM | Oakland City University | @ | St. Catharine | 9-10 | |
| | | Game 2 | Oakland City University | @ | St. Catharine | 13-12 | |
| | 5 | 1:00PM | Davenport University | @ | St. Catharine | 10-0 | |
| | | Game 2 | Davenport University | @ | St. Catharine | 8-1 | |
| | 6 | 12:00PM | Shawnee State | @ | St. Catharine | 2-3 | |
| | | Game 2 | Shawnee State | @ | St. Catharine | 6-1 | |
| | 10 | 2:00PM | Midway College | @ | St. Catharine | 1-4 | |
| | | Game 2 | Midway College | @ | St. Catharine | 5-6 | |
| * | 11 | 1:00PM | Pikeville | @ | St. Catharine | RAIN | |
| * | | Game 2 | Pikeville | @ | St. Catharine | RAIN | |
| | 14 | 2:00PM | Brescia University | @ | St. Catharine | RAIN | |
| | | Game 2 | Brescia University | @ | St. Catharine | RAIN | |
| * | 15 | 3:00PM | St. Catharine | @ | Cumberlands (KY) | 1-10 | |
| * | | Game 2 | St. Catharine | @ | Cumberlands (KY) | 0-10 | |
| | 16 | Game 2 | St. Catharine | @ | Bellarmine University | 4-3 | (9) |
| | | 3:00PM | St. Catharine | @ | Bellarmine University | 0-7 | |
| | 18 | 1:00PM | Union | @ | St. Catharine | 8-0 | |
| | | Game 2 | Union | @ | St. Catharine | 11-3 | |
| * | 20 | 12:00PM | St. Catharine | @ | Lindsey Wilson | 3-2 | |
| * | | Game 2 | St. Catharine | @ | Lindsey Wilson | 1-7 | |
| | 21 | 1:00PM | St. Catharine | @ | Indiana University Southeast | 2-10 | (5) |
| | | Game 2 | St. Catharine | @ | Indiana University Southeast | 1-5 | |
| * | 23 | 2:00PM | St. Catharine | @ | Campbellsville | 0-8 | (5) |
| * | | Game 2 | St. Catharine | @ | Campbellsville | 0-8 | (6) |
| | 24 | 3:00PM | St. Catharine | @ | Shawnee State | 1-4 | |
| | | Game 2 | St. Catharine | @ | Shawnee State | 2-5 | |
| * | 27 | 1:00PM | Georgetown | @ | St. Catharine | 3-0 | |
| * | | 3:00PM | Georgetown | @ | St. Catharine | 9-6 | |
| | 28 | 1:00PM | St. Catharine | @ | Union | RAIN | |
| | | Game 2 | St. Catharine | @ | Union | RAIN | |
| | 30 | 5:00PM | St. Catharine | @ | Asbury College | 7-11 | |
| | | Game 2 | St. Catharine | @ | Asbury College | 1-2 | |
| April |
| | 1 | 3:00PM | St. Catharine | @ | Midway College | 2-1 | (8) |
| | 8 innings |
| | | Game 2 | St. Catharine | @ | Midway College | 8-6 | |
| * | 2 | 2:00PM | Pikeville | @ | St. Catharine | 13-9 | |
| * | | Game 2 | Pikeville | @ | St. Catharine | 0-8 | (5) |
| | 5 innings |
| * | 3 | 12:00PM | Cumberlands (KY) | @ | St. Catharine | 3-4 | |
| * | | Game 2 | Cumberlands (KY) | @ | St. Catharine | 1-3 | |
| * | 6 | 1:00PM | St. Catharine | @ | Pikeville | 2-1 | (8) |
| * | | Game 2 | St. Catharine | @ | Pikeville | 8-4 | |
| * | 10 | 12:00PM | Lindsey Wilson | @ | St. Catharine | 7-2 | |
| * | | Game 2 | Lindsey Wilson | @ | St. Catharine | 3-1 | |
| | 11 | 3:00PM | St. Catharine | @ | Oakland City University | 5-8 | |
| | | Game 2 | St. Catharine | @ | Oakland City University | 1-3 | |
| * | 13 | 3:00PM | St. Catharine | @ | Georgetown | 2-6 | |
| * | | 5:00PM | St. Catharine | @ | Georgetown | 0-6 | |
| | 14 | 3:00PM | Indiana University Southeast | @ | St. Catharine | 7-0 | |
| | | Game 2 | Indiana University Southeast | @ | St. Catharine | 2-3 | |
| * | 16 | 3:00PM | Rio Grande | @ | St. Catharine | 1-0 | |
| * | | Game 2 | Rio Grande | @ | St. Catharine | 3-2 | |
| * | 17 | 12:00PM | Rio Grande | @ | St. Catharine | 7-0 | |
| * | | Game 2 | Rio Grande | @ | St. Catharine | 10-4 | |
| | 19 | 2:00PM | Asbury College | @ | St. Catharine | 4-5 | |
| | | Game 2 | Asbury College | @ | St. Catharine | 5-12 | |
| * | 20 | 3:00PM | Campbellsville | @ | St. Catharine | 7-1 | |
| * | | Game 2 | Campbellsville | @ | St. Catharine | 10-2 | (5) |
| * | 22 | Game 2 | St. Catharine | @ | West Virginia U. Tech | 7-2 | |
| * | | 3:00PM | St. Catharine | @ | West Virginia U. Tech | 8-7 | |
| * | 23 | 12:00PM | St. Catharine | @ | West Virginia U. Tech | 9-6 | |
| * | | Game 2 | St. Catharine | @ | West Virginia U. Tech | 5-4 | |
| | 29 | 3:00PM | St. Catharine | vs. | Campbellsville | 1-9 | (6) |
| | MSC Tournament - Danville, Ky. |
| | 30 | 11:00AM | Pikeville | vs. | St. Catharine | 6-7 | |
| | MSC Tournament -- Danville, Ky. |
| | | 3:30PM | Cumberlands (KY) | vs. | St. Catharine | 0-3 | |
| | Mid-South Conference Tournament - April 30 - May 1, 2010 |
| May |
| | 4 | 6:00PM | St. Catharine | @ | Georgetown | 0-5 | |
| | Mid-South Conference Tournament |
* Conference Event
% Exhibition/Scrimmage Event
Event times are (ET)
