| August |
| % | 21 | 12:00PM | Carson-Newman College | @ | Cumberlands (KY) | 5-1 | |
| | | 4:00PM | Lindsey Wilson | @ | Spring Arbor University | 1-0 | |
| % | | 4:30PM | Thomas More College | @ | Campbellsville | | |
| | Scrimmage - Finley Stadium | |
| % | 22 | 11:30AM | Cumberlands (KY) | @ | Northern Kentucky | 0-11 | |
| | 24 | 4:00PM | SCAD Savannah | @ | Cumberlands (KY) | 3-0 | |
| % | | 7:00PM | Campbellsville | @ | Centre College | RAIN | |
| | Scrimmage | |
| | 26 | 1:00PM | Freed-Hardeman | vs. | Pikeville | 2-2 | (2OT) |
| | Played at Johnson Central High School in Paintsville | |
| | | 8:00PM | SCAD Savannah | @ | Lindsey Wilson | 0-3 | |
| | Lindsey Live: Stats -- Video | |
| | 27 | 3:30PM | Cumberlands (KY) | vs. | Emmanuel College | 0-0 | |
| | @ Union College | |
| | | 6:00PM | Freed-Hardeman | @ | Campbellsville | 1-0 | |
| | Finley Stadium | |
| | 28 | 3:00PM | Georgetown | @ | Brescia University | 4-1 | |
| | | 3:30PM | Cumberlands (KY) | vs. | Cumberland (TN) | 3-2 | (OT) |
| | @ Union College | |
| | 29 | | Shawnee State | @ | Carlow College | 3-2 | |
| | | 2:00PM | Midway College | @ | Pikeville | 0-3 | |
| % | 31 | 5:00PM | West Virginia U. Tech | @ | Southern Virginia University | 2-2 | |
| | | 7:00PM | Lindsey Wilson | @ | Indiana Wesleyan University | 1-3 | |
| September |
| | 1 | 6:00PM | Muskingum College | @ | Rio Grande | 0-2 | |
| | 2010 Regular Season Opener | |
| | 2 | 3:00PM | St. Catharine | @ | Ohio Christian University | 11-0 | |
| | 3 | | Pikeville | vs. | Central Baptist College | 0-1 | |
| | Lions Cup Tournament at Freed-Hardeman | |
| | | 1:00PM | West Virginia U. Tech | @ | Mercyhurst College | 0-7 | |
| | | 4:00PM | Bryan College | vs. | Campbellsville | 0-1 | |
| | Played at Covenant College in Lookout Mtn., Ga. | |
| | | 7:00PM | Rio Grande | @ | Cedarville University | 0-2 | |
| | 4 | 1:30PM | Campbellsville | @ | Covenant College | 0-1 | |
| | | 2:00PM | Rio Grande | vs. | Indiana Institute of Technology | 0-4 | |
| | at Cedarville Classic | |
| | | 3:00PM | Georgetown | @ | Cumberland (TN) | 4-1 | |
| | | 3:00PM | Pikeville | vs. | Lambuth University | 0-3 | |
| | Lions Cup 2010 @ Freed-Hardeman | |
| | 5 | 12:00PM | St. Catharine | @ | Young Harris College | 0-6 | |
| | 6 | | Pikeville | @ | Freed-Hardeman | 0-5 | |
| | Lions Cup Tournament at Freed-Hardeman | |
| | 7 | 4:00PM | St. Catharine | @ | Trevecca Nazarene University | 1-3 | |
| | | 7:00PM | Spalding University | @ | Georgetown | PPD | |
| | Lightning delayed, then PPD, GC was up 4-0 when game was called | |
| | 8 | 2:00PM | Mountain State University | @ | Shawnee State | 1-10 | |
| | | 4:00PM | Bryan College | @ | Cumberlands (KY) | 1-0 | |
| | 9 | 2:00PM | Campbellsville | @ | Union | 2-0 | |
| | Watch Live | |
| | 10 | 6:30PM | Auburn University Montgomery | @ | Lindsey Wilson | 1-2 | |
| | Lindsey Live | |
| | 11 | 2:00PM | Berea College | @ | St. Catharine | 0-8 | |
| | | 4:00PM | Georgetown | @ | Taylor University | 2-1 | |
| | | 7:00PM | Union | @ | West Virginia U. Tech | 3-1 | |
| | 12 | 1:00PM | Georgetown | @ | Marian University | 0-3 | |
| | 13 | 3:00PM | St. Catharine | @ | St. Mary-of-the-Woods College | 0-2 | |
| | 14 | | Union | @ | Cumberlands (KY) | 3-2 | |
| | | 2:00PM | Pikeville | @ | Kentucky Christian | 4-1 | |
| * | | 6:00PM | Campbellsville | @ | Lindsey Wilson | 0-3 | |
| | 15 | 5:00PM | Asbury University | @ | Georgetown | 1-4 | |
| * | | 5:00PM | West Virginia U. Tech | @ | Rio Grande | 1-0 | |
| | | 7:00PM | Shawnee State | vs. | Cincinnati Christian University | 2-0 | |
| | 16 | 2:00PM | Campbellsville | @ | Cumberland (TN) | 3-1 | |
| | | 4:00PM | Brescia University | @ | St. Catharine | PPD | |
| | Postponed to October 28 | |
| | 17 | 8:00PM | Concordia University | @ | Lindsey Wilson | 1-0 | |
| | KELME Classic hosted by Lindsey Wilson | |
| | 18 | 12:00PM | West Virginia U. Tech | @ | Davis & Elkins College | 1-5 | |
| * | | 2:00PM | Pikeville | @ | St. Catharine | 1-2 | |
| * | | 5:00PM | Shawnee State | @ | Georgetown | 0-4 | |
| | Kid's Night | |
| | | 8:00PM | California Baptist University | @ | Lindsey Wilson | 1-0 | |
| | KELME Classic hosted by Lindsey Wilson | |
| | 20 | 3:00PM | Shawnee State | @ | Ohio Christian University | 5-0 | |
| | | 4:00PM | Rio Grande | @ | Alderson-Broaddus College | 0-3 | |
| | Time TBA | |
| * | 21 | 3:00PM | Lindsey Wilson | @ | Pikeville | 4-0 | |
| | | 4:00PM | West Virginia U. Tech | @ | Mountain State University | 4-2 | |
| | | 7:00PM | Trevecca Nazarene University | @ | Campbellsville | 1-0 | |
| | Finley Stadium | |
| | 22 | 3:00PM | Spalding University | @ | St. Catharine | 2-5 | |
| | | 6:00PM | Union | @ | Georgetown | 2-1 | |
| | | 6:00PM | Cumberlands (KY) | @ | Milligan College | 0-0 | (2OT) |
| * | 23 | 2:00PM | Shawnee State | @ | West Virginia U. Tech | 2-1 | |
| % | | 4:00PM | Lindsey Wilson | @ | Campbellsville | 0-0 | |
| | Tiger Soccer Field | |
| * | 24 | 7:00PM | Rio Grande | @ | Campbellsville | 0-3 | |
| | Finley Stadium | |
| | | 8:00PM | Lee University | @ | Lindsey Wilson | 2-0 | |
| * | 25 | 1:00PM | Georgetown | @ | Cumberlands (KY) | 3-4 | |
| * | | 1:00PM | St. Catharine | @ | Shawnee State | 1-5 | |
| | Alumni Weekend | |
| | | 1:00PM | Pikeville | @ | Mountain State University | 7-1 | |
| | | 7:00PM | Alderson-Broaddus College | @ | West Virginia U. Tech | 3-0 | |
| | 27 | 5:00PM | West Virginia U. Tech | @ | Wheeling Jesuit University | 0-4 | |
| * | 28 | 3:00PM | Campbellsville | @ | St. Catharine | 6-0 | |
| | | 5:00PM | Georgetown | @ | Trevecca Nazarene University | 2-0 | |
| * | | 5:00PM | Cumberlands (KY) | @ | Lindsey Wilson | 1-3 | |
| * | 29 | 5:00PM | Shawnee State | @ | Rio Grande | 1-2 | |
| * | 30 | 7:00PM | West Virginia U. Tech | @ | Pikeville | 0-1 | |
| | | 7:00PM | Cincinnati Christian University | @ | Campbellsville | 0-4 | |
| | Finley Stadium | |
| October |
| * | 1 | 11:00AM | Lindsey Wilson | @ | West Virginia U. Tech | 9-0 | |
| * | 2 | 1:00PM | Lindsey Wilson | @ | Shawnee State | 8-1 | |
| % | | 1:00PM | Asbury University | @ | Campbellsville | | |
| | Tiger Soccer Field | |
| | | 2:00PM | Cumberlands (KY) | @ | Lincoln Memorial University | 1-5 | |
| | | 4:00PM | Mount Vernon Nazarene College | @ | Georgetown | 1-0 | |
| | | 8:00PM | Rio Grande | @ | University of Charleston | 0-7 | |
| | 5 | 3:00PM | Bluefield College | @ | West Virginia U. Tech | 0-1 | (2OT) |
| | | 6:00PM | Mountain State University | @ | Rio Grande | 0-2 | |
| * | | 7:00PM | Cumberlands (KY) | @ | Campbellsville | 3-2 | (OT) |
| | Finley Stadium | |
| * | 6 | 7:00PM | Shawnee State | @ | Pikeville | 3-1 | |
| | 7 | 4:00PM | Campbellsville | @ | Midway College | 8-0 | |
| * | | 6:00PM | St. Catharine | @ | Georgetown | 0-4 | |
| | 8 | 4:00PM | Shawnee State | @ | Kentucky Christian | 5-1 | |
| | | 8:00PM | William Carey University | vs. | Lindsey Wilson | 1-2 | |
| | @ Decatur, Ala. | |
| * | 9 | 1:00PM | Rio Grande | @ | Cumberlands (KY) | 2-4 | |
| * | | 2:00PM | West Virginia U. Tech | @ | St. Catharine | 1-2 | |
| * | | 6:00PM | Pikeville | @ | Campbellsville | 0-6 | |
| | Finley Stadium | |
| | 12 | 2:00PM | Pikeville | @ | Tennessee Temple | 3-2 | (OT) |
| | | 3:00PM | West Virginia U. Tech | @ | Concord College | 0-6 | |
| | | 3:00PM | Asbury University | @ | Cumberlands (KY) | 1-2 | |
| * | | 6:00PM | Georgetown | @ | Lindsey Wilson | 0-3 | |
| | | 6:00PM | St. Catharine | @ | Berea College | 8-0 | |
| | 13 | 3:00PM | Rio Grande | @ | Ohio Valley University | 1-0 | |
| | 14 | 5:00PM | Milligan College | @ | Georgetown | 2-0 | |
| | 16 | 1:00PM | St. Catharine | @ | Johnson University | 10-0 | |
| * | | 2:00PM | Pikeville | @ | Cumberlands (KY) | 0-6 | |
| * | | 4:00PM | Rio Grande | @ | Georgetown | 0-4 | |
| | Homecoming | |
| | | 4:00PM | Shawnee State | @ | Indiana Institute of Technology | 0-5 | |
| | | 4:30PM | Lindsey Wilson | @ | St. Leo University | 1-2 | (OT) |
| * | | 5:00PM | Campbellsville | @ | West Virginia U. Tech | 4-0 | |
| | 19 | 3:00PM | Walsh University | @ | Shawnee State | 1-0 | |
| | CCFA Day | |
| * | | 5:00PM | St. Catharine | @ | Rio Grande | 0-2 | |
| | Practice Field | |
| * | | 7:00PM | Georgetown | @ | Campbellsville | 2-1 | |
| | Finley Stadium | |
| * | 21 | 2:00PM | Cumberlands (KY) | @ | St. Catharine | 4-2 | |
| | | 4:00PM | West Virginia U. Tech | @ | Point Park College | 1-2 | |
| * | 22 | 4:00PM | Pikeville | @ | Georgetown | 0-2 | |
| * | 23 | 1:00PM | Campbellsville | @ | Shawnee State | 7-1 | |
| * | | 1:00PM | West Virginia U. Tech | @ | Cumberlands (KY) | 3-2 | |
| | Senior Day | |
| | | 4:00PM | Midway College | @ | St. Catharine | 0-9 | |
| * | | 6:00PM | Rio Grande | @ | Lindsey Wilson | 0-8 | |
| * | 25 | 5:00PM | Pikeville | @ | Rio Grande | 1-3 | |
| | Practice Field | |
| * | | 6:00PM | St. Catharine | @ | Lindsey Wilson | 0-7 | |
| | 26 | 3:00PM | Tennessee Wesleyan | @ | Cumberlands (KY) | CNCL | |
| | Game cancelled due to weather | |
| * | 27 | 5:00PM | West Virginia U. Tech | @ | Georgetown | 1-3 | |
| | | 7:00PM | Pikeville | @ | Berea College | 11-1 | |
| | 30 | 12:00PM | West Virginia U. Tech | @ | Ohio Valley University | 1-2 | |
| | | 12:30PM | Campbellsville | @ | Asbury University | 1-2 | |
| * | | 2:00PM | Cumberlands (KY) | @ | Shawnee State | 0-1 | |
| | | 6:00PM | Midway College | @ | Rio Grande | 0-1 | |
| | Forfeit | |
| | 31 | 7:00PM | Lindsey Wilson | @ | Martin Methodist College | 0-1 | |
| November |
| | 2 | | Pikeville | @ | West Virginia U. Tech | 0-5 | |
| | Mid-South Conference Tournament -- Opening Round | |
| | | 3:00PM | Tennessee Wesleyan | @ | Cumberlands (KY) | 2-1 | |
| | game moved from Oct 26th due to weather | |
| | | 7:00PM | Bethel | @ | Campbellsville | 0-2 | |
| | Finley Stadium | |
| | 6 | 11:00AM | West Virginia U. Tech | @ | Lindsey Wilson | 0-9 | |
| | Mid-South Conference Tournament -- Quarterfinals | |
| | | 12:00PM | Rio Grande | @ | Cumberlands (KY) | 1-1 | (2OT) |
| | Mid-South Conference Tournament - Cumberlands advances 6-5 on PKs | |
| | | 12:00PM | St. Catharine | @ | Georgetown | 0-5 | |
| | MSC Tournament Quarterfinals | |
| | | 5:00PM | Shawnee State | @ | Campbellsville | 0-1 | |
| | MSC Tournament Quarterfinals - Finley Stadium | |
| | 10 | 12:00PM | Lindsey Wilson | vs. | Campbellsville | 1-0 | |
| | Mid-South Conference Tournament Semifinals -- Rio Grande, Ohio | |
| | | 2:30PM | Cumberlands (KY) | vs. | Georgetown | 2-4 | |
| | MSC Tournament Semifinals - Rio Grande, Ohio | Watch Live | |
| | 11 | 5:00PM | Georgetown | vs. | Lindsey Wilson | 0-3 | |
| | MSC Tournament Finals | |
| | 19 | 4:00PM | Tennessee Temple | @ | Campbellsville | 0-6 | |
| | NCCAA Mid-East Region Semifinal - Finley Stadium - Live Stats | |
| | 20 | 2:00PM | Cornerstone University | @ | Lindsey Wilson | 0-3 | |
| | NAIA National Tournament Opening Round | |
| | | 6:00PM | King College | @ | Campbellsville | 1-0 | (2OT) |
| | NCCAA Mid-East Region Championship - Finley Stadium - Live Stats | Live Video | |
| | 30 | 5:00PM | Robert Morris College | vs. | Lindsey Wilson | 2-0 | |
| | NAIA National Championship Second Round - Decatur, Ala. | |
