| August |
| % | 20 | 2:30PM | West Virginia Wesleyan | @ | West Virginia U. Tech | 0-0 | |
| % | | 4:00PM | Cumberlands (KY) | vs. | Lincoln Memorial University | 1-2 | |
| | Scrimmage @ Union College | |
| % | 21 | 6:30PM | Thomas More College | @ | Campbellsville | | |
| | Scrimmage - Finley Stadium | |
| | | 8:00PM | Saint Xavier University | @ | Lindsey Wilson | 0-1 | |
| | Lindsey Live: Stats & Video | |
| % | 24 | 6:00PM | Maryville College | @ | Cumberlands (KY) | 1-2 | |
| | 25 | 7:00PM | Houghton College | @ | Rio Grande | 0-2 | |
| | 2010 Season Opener | |
| | 27 | 7:00PM | Grace College | @ | Rio Grande | 0-7 | |
| | D. Wayne Evans Classic | |
| | | 8:00PM | Freed-Hardeman | @ | Campbellsville | 0-4 | |
| | Finley Stadium | |
| % | 28 | 3:00PM | West Virginia U. Tech | @ | Concord College | 1-3 | |
| | | 4:00PM | Georgetown | @ | Brescia University | 2-3 | |
| | | 7:00PM | Spring Arbor University | @ | Rio Grande | 0-4 | |
| | D. Wayne Evans Classic | |
| * | | 7:00PM | Lindsey Wilson | vs. | Pikeville | 6-0 | |
| | | 7:30PM | Cumberlands (KY) | @ | Bryan College | 0-0 | (2OT) |
| September |
| | 2 | 5:00PM | St. Catharine | @ | Ohio Christian University | 4-3 | |
| | | 7:00PM | West Virginia U. Tech | @ | West Virginia Wesleyan | 1-4 | |
| | 3 | | Pikeville | @ | Freed-Hardeman | 1-4 | |
| | 2010 Lions Cup | |
| | | 4:00PM | Georgetown | @ | Aquinas College | 1-2 | |
| | Fort Wayne Classic | |
| | | 7:00PM | Indiana Institute of Technology | vs. | Campbellsville | 1-3 | |
| | Univ. St. Francis Labor Day Tournament - Fort Wayne, Ind. | |
| | 4 | | Pikeville | vs. | Johnson University | 1-3 | |
| | 2010 Lions Cup | |
| | | 1:00PM | Georgetown | @ | Davenport University | 0-4 | |
| | Fort Wayne Classic | |
| | | 4:00PM | Campbellsville | @ | University of Saint Francis | 3-1 | |
| | Univ. St. Francis Labor Day Tournament - Fort Wayne, Ind. | |
| | | 4:00PM | Cumberlands (KY) | @ | Southern Polytechnic State University | 1-1 | (2OT) |
| | 2 Ovetime Draw | |
| * | | 7:00PM | Shawnee State | @ | Rio Grande | 0-8 | |
| | 5 | 2:00PM | St. Catharine | @ | Young Harris College | 0-0 | |
| | 2 OT | |
| | | 2:00PM | Lindsey Wilson | vs. | Graceland University | 2-0 | |
| | 6 | 4:30PM | Lindsey Wilson | @ | Lindenwood University | 1-2 | |
| | 7 | 5:00PM | Marian University | @ | Georgetown | 1-0 | (OT) |
| | | 6:00PM | St. Catharine | @ | Trevecca Nazarene University | 0-2 | |
| | | 7:00PM | West Virginia U. Tech | @ | Southern Indiana | 0-2 | |
| | 8 | | Ohio Valley University | @ | Shawnee State | 2-3 | |
| | | 12:00PM | West Virginia U. Tech | @ | Kentucky Wesleyan University | 0-2 | |
| | | 2:30PM | Pikeville | vs. | Benedictine University | 0-3 | |
| | Home contest for PC played at Prestonsburg, Ky. | |
| | | 8:00PM | Berea College | @ | Campbellsville | 0-6 | |
| | Finley Stadium | |
| | 10 | 3:00PM | Oakland City University | @ | St. Catharine | 2-0 | |
| | | 4:00PM | Campbellsville | @ | Tennessee Temple | 7-0 | |
| | | 5:00PM | Rio Grande | vs. | Indiana Wesleyan University | 3-1 | |
| | Cedarville Tournament | |
| | | 8:00PM | Union | @ | Georgetown | 1-2 | |
| | Georgetown Classic Tournament 2010 | |
| | | 8:30PM | Auburn University Montgomery | @ | Lindsey Wilson | 0-0 | |
| | Game suspended due to unplayable field conditions due to heavy rains. Game halted at the 78:55 mark. Game ends in 0-0 tie. | |
| | 11 | 3:00PM | Lee University | @ | Cumberlands (KY) | 1-1 | (2OT) |
| | 3rd DOT draw in as many games | |
| | | 4:00PM | Taylor University | @ | Georgetown | 4-0 | |
| | | 4:30PM | Rio Grande | vs. | Bethel College | 7-0 | |
| | Cedarville Tournament | |
| | 12 | 2:00PM | Shawnee State | @ | Berea College | 3-1 | |
| | 14 | | Pikeville | @ | Kentucky Christian | 2-0 | |
| | | 4:00PM | Union | @ | Cumberlands (KY) | 0-5 | |
| | Live Radio: http://client.stretchinternet.com/client/cumberlands.portal# | |
| | | 5:00PM | Shawnee State | @ | Cedarville University | 1-2 | |
| * | 15 | 7:00PM | West Virginia U. Tech | @ | Rio Grande | 0-4 | |
| * | | 8:00PM | Campbellsville | @ | Lindsey Wilson | 1-4 | |
| | Watch Live | |
| | 16 | 6:00PM | Brescia University | @ | St. Catharine | 2-0 | |
| | 17 | 7:30PM | Bethel College | vs. | Cumberlands (KY) | 1-2 | (OT) |
| * | 18 | 2:00PM | Shawnee State | @ | Georgetown | 4-3 | |
| | | 3:00PM | Lindsey Wilson | vs. | William Carey University | 4-3 | (OT) |
| | @ Decatur, Ala. | |
| * | | 4:00PM | Pikeville | @ | St. Catharine | 0-4 | |
| | | 4:30PM | Cumberlands (KY) | @ | Goshen College | 5-0 | |
| | | 7:00PM | Bluefield College | @ | Campbellsville | 0-4 | |
| | | 7:00PM | Illinois Institute of Technology | @ | Rio Grande | 3-4 | (OT) |
| | 19 | | West Virginia U. Tech | @ | Shephard College | 1-2 | |
| | 20 | 5:00PM | Shawnee State | @ | Ohio Christian University | 2-1 | |
| | | 7:00PM | Brescia University | @ | Campbellsville | 0-2 | |
| | Finley Stadium | |
| | 21 | 6:00PM | Alderson-Broaddus College | @ | West Virginia U. Tech | 2-3 | |
| | 22 | 4:00PM | Rio Grande | @ | Mount Vernon Nazarene College | 3-2 | |
| * | | 4:00PM | Georgetown | @ | Cumberlands (KY) | 1-5 | |
| | | 5:00PM | Spalding University | @ | St. Catharine | 0-1 | |
| | 23 | 7:00PM | West Virginia U. Tech | @ | Bluefield College | 4-1 | |
| | 24 | 5:00PM | Johnson University | @ | Shawnee State | 0-6 | |
| * | 25 | 3:00PM | St. Catharine | @ | Shawnee State | 0-3 | |
| | Alumni Weekend | |
| | | 3:00PM | Asbury University | @ | Cumberlands (KY) | 1-5 | |
| | | 3:00PM | Mountain State University | @ | Pikeville | 7-0 | |
| | | 7:00PM | Lindsey Wilson | @ | Bethel College | 2-1 | (2OT) |
| * | | 7:30PM | Rio Grande | @ | Campbellsville | 2-0 | |
| | Time TBA | |
| * | 28 | 6:00PM | Campbellsville | @ | St. Catharine | 4-1 | |
| | | 7:00PM | Georgetown | @ | Union University | 1-2 | |
| * | | 7:00PM | Cumberlands (KY) | @ | Lindsey Wilson | 0-2 | |
| | 29 | 7:00PM | Shawnee State | @ | Marshall University | 0-3 | |
| | 30 | 4:00PM | Union | @ | St. Catharine | 5-0 | |
| * | | 9:00PM | West Virginia U. Tech | @ | Pikeville | 3-0 | |
| October |
| * | 1 | 2:00PM | Lindsey Wilson | @ | West Virginia U. Tech | 6-3 | |
| | | 4:00PM | Walsh University | @ | Cumberlands (KY) | 1-4 | |
| * | 2 | 4:00PM | Lindsey Wilson | @ | Shawnee State | 7-0 | |
| | | 7:00PM | Roberts Wesleyan College | @ | Rio Grande | 0-6 | |
| | 3 | 2:00PM | Walsh University | @ | Georgetown | 6-1 | |
| | 4 | | Pikeville | @ | Salem International University | 2-2 | |
| | | 6:30PM | Cumberlands (KY) | @ | Lambuth University | | |
| * | 6 | 7:30PM | Cumberlands (KY) | @ | Campbellsville | 2-0 | |
| * | | 9:00PM | Shawnee State | @ | Pikeville | 1-0 | |
| * | 7 | 8:00PM | St. Catharine | @ | Georgetown | 1-3 | |
| | 9 | 3:00PM | Lindsey Wilson | @ | Bethel | 4-1 | |
| * | | 4:00PM | West Virginia U. Tech | @ | St. Catharine | 2-3 | (OT) |
| * | | 7:00PM | Cumberlands (KY) | @ | Rio Grande | 0-2 | |
| * | | 8:00PM | Pikeville | @ | Campbellsville | 0-5 | |
| | Finley Stadium | |
| * | 12 | 7:00PM | Georgetown | @ | Lindsey Wilson | 0-10 | |
| | | 8:00PM | St. Catharine | @ | Berea College | 5-2 | |
| | 13 | 7:00PM | Campbellsville | @ | Cincinnati Christian University | 5-0 | |
| | 14 | 7:00PM | Rio Grande | @ | Cedarville University | 5-2 | |
| | 16 | 12:00PM | Urbana University | @ | Shawnee State | 5-0 | |
| | | 3:00PM | St. Catharine | @ | Johnson University | 3-0 | |
| * | | 4:00PM | Pikeville | @ | Cumberlands (KY) | 0-9 | |
| * | | 6:00PM | Rio Grande | @ | Georgetown | 7-0 | |
| * | | 7:00PM | Campbellsville | @ | West Virginia U. Tech | 1-0 | |
| * | 18 | 3:00PM | Pikeville | @ | Georgetown | 1-3 | |
| * | 19 | 2:00PM | Shawnee State | @ | West Virginia U. Tech | 0-3 | |
| * | | 7:00PM | St. Catharine | @ | Rio Grande | 0-6 | |
| | Time TBA | |
| * | 21 | | Georgetown | @ | Campbellsville | 2-3 | |
| | Finley Stadium | |
| * | | 4:00PM | Cumberlands (KY) | @ | St. Catharine | 2-1 | |
| | 23 | 2:00PM | Berea College | @ | St. Catharine | 0-2 | |
| * | | 3:00PM | Campbellsville | @ | Shawnee State | 1-0 | |
| | Montgomery-Haydon Soccer Field | |
| * | | 3:00PM | West Virginia U. Tech | @ | Cumberlands (KY) | 0-3 | |
| | Senior Day | |
| * | | 8:00PM | Rio Grande | @ | Lindsey Wilson | 2-1 | (OT) |
| | 25 | 4:00PM | Malone College | @ | Shawnee State | 1-0 | |
| * | | 8:00PM | St. Catharine | @ | Lindsey Wilson | 0-9 | |
| | 26 | 3:00PM | Campbellsville | @ | Tennessee Wesleyan | 0-3 | |
| | | 7:00PM | Cumberlands (KY) | @ | Milligan College | 2-0 | |
| * | 27 | 7:00PM | West Virginia U. Tech | @ | Georgetown | 5-3 | |
| | 28 | 7:30PM | Asbury University | @ | Campbellsville | 0-1 | |
| | Finley Stadium | |
| * | 29 | 7:00PM | Pikeville | @ | Rio Grande | 0-11 | |
| | | 8:00PM | Martin Methodist College | @ | Lindsey Wilson | 0-1 | |
| | Lindsey Live | |
| * | 30 | 4:00PM | Cumberlands (KY) | @ | Shawnee State | 10-0 | |
| | Senior Day | |
| | | 7:00PM | Georgetown | @ | Asbury University | 1-1 | (2OT) |
| November |
| | 1 | 4:00PM | Cincinnati Christian University | @ | Shawnee State | 1-4 | |
| | 2 | | Campbellsville | vs. | TBA | | |
| | NCCAA National Tournament - Kissimmee, Fla. | |
| | | 2:00PM | Cumberlands (KY) | @ | Bethel | 1-0 | (2OT) |
| | | 3:00PM | Pikeville | @ | St. Catharine | 1-5 | |
| | Play in game MSC Tournament | |
| | | 7:00PM | Walsh University | @ | Rio Grande | 1-8 | |
| | 5 | 8:00PM | Georgetown | @ | Lindsey Wilson | 0-4 | |
| | Mid-South Conference Tournament | |
| | 6 | 12:00PM | St. Catharine | @ | Rio Grande | 0-13 | |
| | MSC Tournament | |
| | | 2:00PM | Shawnee State | @ | Cumberlands (KY) | 0-6 | |
| | Mid-South Conference Tournament | |
| | | 7:30PM | West Virginia U. Tech | @ | Campbellsville | 0-4 | |
| | MSC Tournament Quarterfinals - Finley Stadium | |
| | 10 | 5:00PM | Cumberlands (KY) | vs. | Lindsey Wilson | 0-2 | |
| | MSC Tournament Semifinals - Rio Grande, Ohio | Watch Live | |
| | | 7:30PM | Campbellsville | @ | Rio Grande | 0-4 | |
| | MSC Tournament - Semifinal Round | |
| | 11 | 7:30PM | Lindsey Wilson | @ | Rio Grande | 0-2 | |
| | MSC Tournament Finals - Rio Grande, Ohio | |
| | 19 | 7:00PM | Campbellsville | vs. | King College | 1-0 | (OT) |
| | NCCAA Mid-East Region Semifinal - Covenant College - Lookout Mountain, Ga. | |
| | 20 | 1:00PM | Bethel College | @ | Rio Grande | 1-2 | |
| | NAIA National Tournament - Opening Round | |
| | | 2:00PM | Oakland City University | vs. | Campbellsville | 2-5 | |
| | NCCAA Mid-East Region Championship - Covenant College - Lookout Mountain, Ga. | |
| | | 5:00PM | Southern Polytechnic State University | @ | Lindsey Wilson | 2-1 | |
| | NAIA National Tournament Opening Round | |
| | 29 | 12:00PM | Rio Grande | vs. | Bethel | 1-2 | |
| | NAIA National Tournament - Second Round | |
| December |
| | 1 | 7:45PM | Campbellsville | vs. | Cedarville University | 0-4 | |
| | NCCAA National Tournament - Kissimmee, Fla. | |
| | 2 | 5:00PM | Campbellsville | vs. | Hope International University | 2-1 | (2OT) |
| | NCCAA National Tournament - Kissimmee, Fla. | |
| | 4 | 10:00AM | Southwestern Christian University | vs. | Campbellsville | 2-3 | |
| | NCCAA National Tournament - Kissimmee, Fla. - 5th Place | |
